The effect of pharmacotherapy for attention deficit hyperactivity disorder on risk of seizures in pediatric patients as assessed in an insurance claims database.
Curr Drug Saf
; 3(2): 123-31, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18690990
ABSTRACT
PURPOSE:
To estimate the rate of new-onset seizure in ADHD patients in relation to ADHD pharmacotherapy.METHODS:
A retrospective cohort study of 34,727 patients, ages 6 to 17, with at least two insurance claims bearing ADHD diagnoses during 2003 in the UnitedHealthcare database. Incidence of seizure was calculated for observation time during treatment with atomoxetine and stimulants/bupropion.RESULTS:
Seizure incidence among ADHD patients was 4.5/1,000 person-years (p-y; 95% confidence interval 3.7 - 5.5). ADHD patients who received any ADHD medication had an incidence of 3.8/1,000 p-y (3.0 - 4.8) compared to 8.7 (5.8 - 12.4) for patients who did not receive any ADHD medication. The relative risk (RR) for current vs non-use of atomoxetine was 1.1 (0.6 - 2.1). For stimulants and bupropion, the RR for current vs non-use was 0.8 (0.6 - 1.3). Elevated seizure risks were found in association with central nervous system (CNS) disease (OR 3.9, 1.2 - 10.9), CNS medications (OR 2.2, 1.3 - 3.6), metabolic disease (OR 2.9, 1.1 - 6.8), and psychiatric disease risk factors (OR 1.7, 1.1 - 2.6).CONCLUSIONS:
In this study, there was no statistically significant association between use of atomoxetine or stimulants and seizure risk in children ages 6 to 17 years with ADHD and without prior seizure disorder.
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Base de dados:
MEDLINE
Assunto principal:
Propilaminas
/
Transtorno do Deficit de Atenção com Hiperatividade
/
Convulsões
/
Bupropiona
/
Inibidores da Captação de Dopamina
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Inibidores da Captação Adrenérgica
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Estimulantes do Sistema Nervoso Central
/
Formulário de Reclamação de Seguro
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article