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Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.
Hudkins, Robert L; Diebold, James L; Tao, Ming; Josef, Kurt A; Park, Chung Ho; Angeles, Thelma S; Aimone, Lisa D; Husten, Jean; Ator, Mark A; Meyer, Sheryl L; Holskin, Beverly P; Durkin, John T; Fedorov, Alexander A; Fedorov, Elena V; Almo, Steven C; Mathiasen, Joanne R; Bozyczko-Coyne, Donna; Saporito, Michael S; Scott, Richard W; Mallamo, John P.
Afiliação
  • Hudkins RL; Discovery Research, Cephalon, Incorporated, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, USA. rhudkins@cephalon.com
J Med Chem ; 51(18): 5680-9, 2008 Sep 25.
Article em En | MEDLINE | ID: mdl-18714982
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolidinonas / Carbazóis / Modelos Moleculares / MAP Quinase Quinase Quinases / Inibidores de Proteínas Quinases Idioma: En Ano de publicação: 2008 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolidinonas / Carbazóis / Modelos Moleculares / MAP Quinase Quinase Quinases / Inibidores de Proteínas Quinases Idioma: En Ano de publicação: 2008 Tipo de documento: Article