Sequential discontinuation of azathioprine and prednisone in renal transplantation.
Transplant Proc
; 23(4): 2226-7, 1991 Aug.
Article
em En
| MEDLINE
| ID: mdl-1871856
ABSTRACT
We report the time course of rejections in 110 patients of first cadaver kidney grafts entered into a randomized controlled trial of induction ALG vs continuous IV CyA, with both groups receiving Aza for 30 days and Pred for 3 months. There was no difference in 1-year graft or patient survival in the two induction regimens. Despite a slight delay in time to first rejection, the number, severity, and outcome of rejections were the same in both. Fifty percent of patients never had a rejection, and 80% of these were on CyA monotherapy at 1 year vs only 22% in patients with rejections. Thirty-five percent had a rejection in the first month, and one fourth of these had a repeat in the second month. The risk of graft loss was 10% with a first, 38% with a second, and 50% with a third rejection. First rejections occurring after 30 days rarely caused graft loss and rejection after 90 days proved to be unusual.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Ciclosporinas
/
Soro Antilinfocitário
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article