Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages.
J Neuroimmunol
; 204(1-2): 52-7, 2008 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-18771807
ABSTRACT
Leukemia inhibitory factor (LIF) promotes survival of glial cells and neurons during autoimmune and injury responses in the central nervous system (CNS). While various studies indicate that LIF also modulates ongoing inflammatory responses, data on underlying events are lacking. In this study we demonstrate that LIF modulates macrophage function. LIF inhibits the production of oxygen radicals and TNFalpha and stimulates myelin uptake by macrophages. These effects of LIF are accompanied by activation of the JAK/STAT3 signalling pathway. Our findings demonstrate that LIF has anti-inflammatory properties and enhances myelin clearance, implicating that LIF may be an important factor in CNS inflammatory disease.
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Base de dados:
MEDLINE
Assunto principal:
Fagocitose
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Fator de Necrose Tumoral alfa
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Espécies Reativas de Oxigênio
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Macrófagos Peritoneais
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Fator Inibidor de Leucemia
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Bainha de Mielina
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article