Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy.
Atherosclerosis
; 203(2): 371-6, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-18775538
ABSTRACT
OBJECTIVE:
A minor allele variant (rs3798220) of apolipoprotein(a) has been reported to be associated with elevated plasma lipoprotein(a) [Lp(a)] and increased cardiovascular risk. We investigated whether this allele was associated with elevated Lp(a) and cardiovascular risk in the Women's Health Study, a randomized trial of low-dose aspirin, and whether aspirin reduced cardiovascular risk in minor allele carriers. METHODS ANDRESULTS:
Genotypes of rs3798220 were determined for 25,131 initially healthy Caucasian participants. Median Lp(a) levels at baseline were 10.0, 79.5, and 153.9mg/dL for major allele homozygotes, heterozygotes, and minor allele homozygotes, respectively (P<0.0001). During the 9.9 years of follow-up, minor allele carriers (3.7%) in the placebo group had twofold higher risk of major cardiovascular events than non-carriers (age-adjusted hazard ratio (HR)=2.21, 95% CI 1.39-3.52). Among carriers, risk was reduced more than twofold by aspirin for aspirin compared with placebo the age-adjusted HR was 0.44 (95% CI 0.20-0.94); risk was not significantly reduced among non-carriers (age-adjusted HR=0.91, 95% CI 0.77-1.08). This interaction between carrier status and aspirin allocation was significant (P=0.048).CONCLUSIONS:
In the Women's Health Study, carriers of an apolipoprotein(a) variant had elevated Lp(a), doubled cardiovascular risk, and appeared to benefit more from aspirin than non-carriers.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas A
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Polimorfismo Genético
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Doenças Cardiovasculares
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Anti-Inflamatórios não Esteroides
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Aspirina
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article