Long-term follow-up of patients with adult-onset subacute sclerosing panencephalitis.
J Neurol Sci
; 275(1-2): 113-6, 2008 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-18783800
ABSTRACT
Subacute sclerosing panencephalitis (SSPE) is a rare infectious central nervous system disease with a poor prognosis. Nineteen patients, 18 males and one female, ranging in age from 18 to 22, mean 19.6+/-1.5 years with SSPE were evaluated. We treated 9 patients with oral isoprinosine and 10 patients with alpha-interferon plus oral isoprinosine and followed up for 16 to 160 months. Of the 9 patients treated with oral isoprinosine, 7 (77.7%) died, one stabilized, and one showed progression. Seven (70%) of 10 patients treated with alpha-interferon plus oral isoprinosine died, one showed progression, and stabilization was observed in two patients. Thus, we suggest that isoprinosine alone or in combination with intraventricular interferon did not change the prognosis in long-term follow-up periods.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Panencefalite Esclerosante Subaguda
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Interferon-alfa
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Fatores Imunológicos
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Inosina Pranobex
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article