A mutation in hairless dogs implicates FOXI3 in ectodermal development.
Science
; 321(5895): 1462, 2008 Sep 12.
Article
em En
| MEDLINE
| ID: mdl-18787161
ABSTRACT
Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Displasia Ectodérmica
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Mutação da Fase de Leitura
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Doenças do Cão
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Cães
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Ectoderma
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Fatores de Transcrição Forkhead
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article