Small RNA-directed heterochromatin formation in the context of development: what flies might learn from fission yeast.
Biochim Biophys Acta
; 1789(1): 3-16, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-18789407
ABSTRACT
A link between the RNAi system and heterochromatin formation has been established in several model organisms including Schizosaccharomyces pombe and Arabidopsis thaliana. However, the data to support a role for small RNAs and the associated machinery in transcriptional gene silencing in animal systems is more tenuous. Using the S. pombe system as a model, we analyze the role of small RNA pathway components and associated small RNAs in regulating transposable elements and potentially directing heterochromatin formation at these elements in Drosophila melanogaster.
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Base de dados:
MEDLINE
Assunto principal:
Schizosaccharomyces
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RNA Fúngico
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Elementos de DNA Transponíveis
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Heterocromatina
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Inativação Gênica
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RNA Interferente Pequeno
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article