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Functional analysis of the SUMOylation pathway in Drosophila.
Talamillo, Ana; Sánchez, Jonatan; Barrio, Rosa.
Afiliação
  • Talamillo A; Functional Genomics Unit, CIC bioGUNE, Technology Park, Building 801-A, 48160 Derio, Bizkaia, Spain.
Biochem Soc Trans ; 36(Pt 5): 868-73, 2008 Oct.
Article em En | MEDLINE | ID: mdl-18793153
ABSTRACT
SUMOylation, a reversible process used as a 'fine-tuning' mechanism to regulate the role of multiple proteins, is conserved throughout evolution. This post-translational modification affects several cellular processes by the modulation of subcellular localization, activity or stability of a variety of substrates. A growing number of proteins have been identified as targets for SUMOylation, although, for many of them, the role of SUMO conjugation on their function is unknown. The use of model systems might facilitate the study of SUMOylation implications in vivo. In the present paper, we have compiled what is known about SUMOylation in Drosophila melanogaster, where the use of genetics provides new insights on SUMOylation's biological roles.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas de Drosophila / Proteínas Modificadoras Pequenas Relacionadas à Ubiquitina / Drosophila melanogaster Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas de Drosophila / Proteínas Modificadoras Pequenas Relacionadas à Ubiquitina / Drosophila melanogaster Idioma: En Ano de publicação: 2008 Tipo de documento: Article