Bone marrow stroma cells regulate TIEG1 expression in acute lymphoblastic leukemia cells: role of TGFbeta/BMP-6 and TIEG1 in chemotherapy escape.
Int J Cancer
; 123(12): 2759-66, 2008 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-18798273
ABSTRACT
The bone marrow microenvironment regulates early B lymphopoiesis and protects leukemia cells against chemotherapy treatment, thus the microenvironment may serve as a sanctuary site for these cells. Yet, few factors that contribute to this process are known. We have explored the role of transforming growth factor beta (TGFbeta) and bone morphogenetic protein-6 (BMP-6) and one target gene, TGFbeta inducible early gene 1 (TIEG1), in the communication between stroma cells and acute lymphoblastic leukemia (ALL) cell lines and their escape from chemotherapy. Here, we have demonstrated TIEG1 expression in both normal B progenitor cells and ALL cells, which increased rapidly upon TGFbeta and BMP-6 treatment. Stimulation with TGFbeta or BMP-6, as well as overexpression of TIEG1 inhibited proliferation. Furthermore, interaction with stroma cells induced TIEG1 expression in ALL cells, inhibited their proliferation and protected the cells against chemotherapeutic treatment. Similarly, treatment with TGFbeta or BMP-6, as well as overexpression of TIEG1, protected ALL cells against chemotherapy-induced cell death. These data suggest that TGFbeta and BMP-6 in the bone marrow microenvironment allow leukemia cells to escape therapy. Further, the data indicate that TIEG1 might be involved in mediating this effect from the microenvironment onto the leukemia cells.
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1
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
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Fator de Crescimento Transformador beta
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Fatores de Transcrição de Resposta de Crescimento Precoce
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Fatores de Transcrição Kruppel-Like
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Proteína Morfogenética Óssea 6
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Antineoplásicos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article