Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.
AIDS
; 22(16): 2214-7, 2008 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-18832887
ABSTRACT
Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/l) through a carbohydrate-dependent interaction (50% inhibitory concentration for D-fructose, 12 mmol/l). This is the first report of a neutralizing HIV antibody displaying cross-reactivity with another pathogen, revealing that the carbohydrate neutralization determinant of HIV, defined by 2G12, is more widespread amongst immunogenic, microbial surfaces than previously recognized.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Candida
/
Proteína gp120 do Envelope de HIV
/
Mimetismo Molecular
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article