Application of liquid-based preparation to fine needle aspiration cytology in breast cancer.
Acta Cytol
; 52(5): 591-6, 2008.
Article
em En
| MEDLINE
| ID: mdl-18833823
ABSTRACT
OBJECTIVE:
To examine the performance of liquid-based cytology (LBC) in breast cytology to confirm the diagnosis of carcinoma. STUDYDESIGN:
Using cell clusters directly scratched from surgically removed tumor masses, we examined the immunocytochemistry, molecular biology and cytomorphology of the specimens.RESULTS:
LBC was very useful for gene analysis and evaluating the immunocytochemistry. The cytologic features of LBC were slightly different from those ofa conventional aspiration cytology smear.CONCLUSION:
LBC is a promising method for improving the standardization ofpreparations in breast cytology, although care should be taken to account for its characteristic cytologic features. The quantitative analysis of HER-2 mRNA correlated with the results of immunohistochemistry.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Biomarcadores Tumorais
/
Carcinoma Ductal de Mama
/
Adenocarcinoma Mucinoso
/
Receptor ErbB-2
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article