Reduced memory B cells in patients with hyper IgE syndrome.
Clin Immunol
; 129(3): 448-54, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-18835223
ABSTRACT
Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
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Memória Imunológica
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Síndrome de Job
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article