Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp.
Bioorg Med Chem
; 16(21): 9588-95, 2008 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-18835720
ABSTRACT
The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p<0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Heparina
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Penaeidae
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Glicosaminoglicanos
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Inflamação
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Anti-Inflamatórios
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Anticoagulantes
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article