Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines.

Bardelle, Catherine; Coleman, Tanya; Cross, Darren; Davenport, Sara; Kettle, Jason G; Ko, Eun Jung; Leach, Andrew G; Mortlock, Andrew; Read, Jon; Roberts, Nicola J; Robins, Peter; Williams, Emma J

Bardelle, Catherine; Coleman, Tanya; Cross, Darren; Davenport, Sara; Kettle, Jason G; Ko, Eun Jung; Leach, Andrew G; Mortlock, Andrew; Read, Jon; Roberts, Nicola J; Robins, Peter; Williams, Emma J.

Afiliação

Bardelle C; AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.

Bioorg Med Chem Lett ; 18(21): 5717-21, 2008 Nov 01.

Article em En | MEDLINE | ID: mdl-18851911

Assuntos

Inibidores de Proteínas Quinases/farmacologia; Pirimidinas/farmacologia; Receptor EphB4/antagonistas & inibidores; Modelos Moleculares; Estrutura Molecular; Inibidores de Proteínas Quinases/química; Pirimidinas/química

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Receptor EphB4 / Inibidores de Proteínas Quinases Idioma: En Ano de publicação: 2008 Tipo de documento: Article

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