Protein-resistant surfaces through mild dopamine surface functionalization.
Chemistry
; 14(34): 10579-84, 2008.
Article
em En
| MEDLINE
| ID: mdl-18924224
ABSTRACT
The synthesis and evaluation of new dopamine-based catechol anchors coupled to poly(ethylene glycol) (PEG) for surface modification of TiO(2) are reported. Dopamine is modified by dimethylamine-methylene (7) or trimethylammonium-methylene (8) groups, and the preparation of mPEG-Glu didopamine polymer 11 is presented. All these PEG polymers allow stable adlayers on TiO(2) to be generated through mild dip-and-rinse procedures, as evaluated both by variable angle spectroscopic ellipsometry and X-ray photoelectron spectroscopy. The resulting surfaces substantially reduced protein adsorption upon exposure to full human serum.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Albumina Sérica
/
Dopamina
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article