Antioxidant and oxidative stress status in type 2 diabetes and diabetic foot ulcer.
S Afr Med J
; 98(8): 614-7, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18928040
ABSTRACT
OBJECTIVE:
Oxidative stress (OS) has been implicated in the aetiology and progression of diabetic complications including diabetic foot ulcer. In this study, the levels of lipid peroxides (LPO) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as well as the enzymatic antioxidant activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in type 2 diabetes mellitus and diabetic foot ulcer subjects were assessed and compared with apparently healthy normal subjects to understand the involvement of OS in the subjects.METHOD:
The above-mentioned OS markers were measured in 50 subjects for each of the following groups type 2 diabetes mellitus (DM), diabetic foot ulcer (DF) and non-diabetic control (NC).RESULTS:
Significant elevated values of LPO (39.86%) and 8-OHdG (45.53%) were found in DM subjects compared with the NC subjects. This increase in both parameters was greater for DFsubjects:
80.23% and 53.91% respectively. SOD activities were significantly reduced in DM (14.82%) and DF (4.09%) subjects in contrast with elevated activities of GPx observed in DM (21.87%) and DF (20.94%) subjects. Glycated haemoglobin/fasting plasma glucose (HbA1c/FPG) correlated positively with LPO, 8-OHdG and GPx, whereas a negative correlation was observed for SOD.CONCLUSION:
Increased oxidation subsequent to diabetic conditions induces an over-expression of GPx activity suggesting a compensatory mechanism by the body to prevent further tissue damage in the subjects.
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Base de dados:
MEDLINE
Assunto principal:
Pé Diabético
/
Estresse Oxidativo
/
Diabetes Mellitus Tipo 2
/
Antioxidantes
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article