[Expression of hematopoietic cytokines EPO, SCF and GM-CSF in bone marrow cells of patients with chronic aplastic anemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 16(5): 1100-2, 2008 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-18928604
ABSTRACT
The objective of this study was to investigate the expressions of hematopoietic cytokines EPO, SCF and GM-CSF in bone marrow cells of patients with chronic aplastic anemia (CAA) and their significance. The mRNA expressions of EPO, SCF and GM-CSF from 35 CAA patients and 10 healthy individuals were detected by semi-quantitative RT-PCR. The results showed that the levels of EPO, SCF and GM-CSF in CAA patients were obviously lower than those in the healthy individuals (p < 0.01). It is concluded that the immunity disorder mediated by hematopoietic cytokines is one of the pathogenesis in the CAA patients, it provided theoretical basis for guiding clinical treatment.
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Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Eritropoetina
/
Fator de Células-Tronco
/
Anemia Aplástica
Idioma:
Zh
Ano de publicação:
2008
Tipo de documento:
Article