Synthesis and antifungal activity of (-)-(Z)-dysidazirine.
Org Lett
; 10(22): 5269-71, 2008 Nov 20.
Article
em En
| MEDLINE
| ID: mdl-18937483
ABSTRACT
A short, flexible synthesis of the marine natural product (2 R)-(Z)-dysidazirine (-)-1 has been completed. (-)-1 shows significant antifungal activity across a panel of seven human pathogens, whereas the structural analogue (-)-2, featuring a terminal tert-butyl group, is essentially inactive.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Azirinas
/
Antifúngicos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article