Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).
Bioorg Med Chem Lett
; 18(23): 6231-5, 2008 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-18938080
ABSTRACT
A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar K(i)'s against SYK and potent inhibition in mast cell degranulation assays.
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Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Baço
/
Tiazóis
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Proteínas Tirosina Quinases
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Peptídeos e Proteínas de Sinalização Intracelular
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Inibidores de Proteínas Quinases
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article