Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor.
Bioorg Med Chem Lett
; 18(23): 6093-6, 2008 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-18954983
ABSTRACT
We report the identification of KD5170, a potent mercaptoketone-based Class I and II-histone deacetylase inhibitor that demonstrates broad spectrum cytotoxic activity against a range of human tumor-derived cell lines. KD5170 exhibits robust and sustained histone H3 hyperacetylation in HCT-116 xenograft tumors following single oral or i.v. dose and inhibition of tumor growth following chronic dosing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Sulfonamidas
/
Pró-Fármacos
/
Inibidores Enzimáticos
/
Inibidores de Histona Desacetilases
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article