Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs.
Bioorg Med Chem
; 16(23): 9925-36, 2008 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-18954995
ABSTRACT
The synthesis of several (3-noradamantyl)amines, [(3-noradamantyl)methyl]amines, (3,7-dimethyl-1-bisnoradamantyl)amines, and [(3,7-dimethyl-1-bisnoradamantyl)methyl]amines is reported. They were evaluated against a wide range of viruses and one of them inhibited the cytopathicity of influenza A virus at a concentration similar to that of amantadine. Several of the new polycyclic amines show an interesting activity as NMDA receptor antagonists. A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Amantadina
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article