Abnormal neutrophil chemotactic activity in children with congenital insensitivity to pain with anhidrosis (CIPA): the role of nerve growth factor.
Clin Immunol
; 130(3): 365-72, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-18955016
ABSTRACT
A 1926-ins-T mutation in the TrkA gene encoding the tyrosine kinase receptor for nerve growth factor (NGF) was previously documented in patients with congenital insensitivity to pain with anhidrosis (CIPA). These patients suffer from skin lacerations which often evolve into deep tissue infections. Abnormality in neutrophil functions may explain this high rate of severe infections. In this study we show that chemotaxis was significantly (P<0.001) suppressed in patients' neutrophils, compared to healthy controls. Although NGF alone did not exert a chemotactic effect, its presence enhanced both migration toward fMLP and phosphorylation of MAP kinases (ERK and JNK) in neutrophils from healthy controls, but not in neutrophils from CIPA patients. The significantly impaired chemotactic activity of neutrophils from a CIPA patient, which has been attributed to the molecular defect in the TrkA receptor, may contribute to the high rate of infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Insensibilidade Congênita à Dor
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Fator de Crescimento Neural
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Hipo-Hidrose
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Neutrófilos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article