A water-soluble carbon monoxide-releasing molecule (CORM-3) lowers intraocular pressure in rabbits.
Br J Ophthalmol
; 93(2): 254-7, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-18977789
ABSTRACT
BACKGROUND:
Carbon monoxide-releasing molecules (CORMs) are a novel group of substances that are capable of modulating physiological functions via the liberation of CO.AIMS:
This study was undertaken to investigate the effects of CORM-3, a water-soluble CO-releasing agent, on two rabbit models of ocular hypertension.METHODS:
Ocular hypertension was induced by injecting alpha-chymotrypsin in the rabbit eye. The dose-response effect of CORM-3 on IOP was assessed by topical administration of the drug (0.001, 0.01, 0.1 and 1%). Ocular hypertension was also obtained by weekly subconjunctival injection of betamethasone, and animals were treated topically with CORM-3. A group of animals in both models was treated with the inactive form of the drug (iCORM-3).RESULTS:
CORM-3 induced a dose-dependent reduction in IOP in rabbits treated with alpha-chymotrypsin. A similar reduction in IOP was observed in rabbits with betamethasone-induced ocular hypertension treated with the drug. Treatment with the iCORM-3 had no effect on IOP in both models.CONCLUSIONS:
Treatment with CORM-3 is associated with a reduction in IOP in two different rabbit models of ocular hypertension. These results support previous findings on the effect of haem oxygenase-derived CO on IOP and suggest a direct involvement of CO system in the regulation of ocular pressure probably through the modulation of aqueous humour dynamics.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Hipertensão Ocular
/
Anti-Hipertensivos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article