Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic, and neural cell adhesion molecule in preeclampsia.
J Matern Fetal Neonatal Med
; 21(11): 831-8, 2008 Nov.
Article
em En
| MEDLINE
| ID: mdl-18979395
ABSTRACT
OBJECTIVE:
To investigate placental expression of insulin-like growth factor-I (IGF-I), fibroblast growth factor-basic (FGF-b), and neural cell adhesion molecule (N-CAM) in preeclampsia. STUDYDESIGN:
An immunohistochemical analysis using IGF-I, FGF-b, and N-CAM antibodies was conducted on 4% paraformaldehyde-fixed placental tissues of preeclamptic patients (N = 14) and normotensive pregnant subjects (N = 10). Immunostaining patterns of chorionic villi and amniochorionic membranes were assessed.RESULTS:
Significantly increased FGF-b and N-CAM immunoreactivities in cytotrophoblasts and increased FGF-b immunoreactivity in capillary endothelium of chorionic villi of preeclamptic subjects were noted. Significantly increased FGF-b and decreased N-CAM immunoreactivities in extravillous trophoblasts and decidual cells of amniochorionic membranes obtained from preeclamptic subjects were demonstrated. Additionally, a significantly increased IGF-I immunoreactivity was shown in decidual cells of preeclamptic cases.CONCLUSION:
Investigation of the regional distribution of IGF-I, FGF-b, and N-CAM at the maternal-fetal interface establishes a better understanding of cell-specific altered growth processes, which may be associated with the pathogenesis of preeclampsia.
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Base de dados:
MEDLINE
Assunto principal:
Placenta
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Pré-Eclâmpsia
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Fator de Crescimento Insulin-Like I
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Fator 2 de Crescimento de Fibroblastos
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Moléculas de Adesão de Célula Nervosa
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article