Cancer metabolism and the dynamics of metastasis.
J Theor Biol
; 256(3): 305-10, 2009 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-18996401
ABSTRACT
Cancer growth dynamics, commonly simulated with a Gompertzian model, is analyzed in the framework of a more recent and realistic model. In particular, we consider the setting of a tumor embedded in a host organ and investigate their interaction. We assume that, at least in some cases, tumor metastasis may be triggered by an 'energetic crisis', when the tumor exceeds the 'carrying capacity' of the host organ. As a consequence, dissemination of clusters of cancer cells is set in motion, with a statistical probability given by a Poisson distribution. The model, although still at a preclinical level, is fully quantitative and is applied, as an example, to the case of prostate cancer. The results confirm that, at least for the more aggressive cancers, metastasis starts very early during tumorigenesis and a quantitative link is found between the tumor's doubling time, its 'aggressiveness' and the metastatic potential.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Modelos Estatísticos
/
Neoplasias
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article