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Cofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors.
Yan, Benedict; Yap, Celestial T; Wang, Shi; Lee, Chi Kuen; Koh, Shiuan; Omar, Mohd Feroz; Salto-Tellez, Manuel; Kumarasinghe, Marian Priyanthi.
Afiliação
  • Yan B; Department of Pathology, National University Hospital and Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Acta Histochem ; 112(1): 101-6, 2010.
Article em En | MEDLINE | ID: mdl-19004480
ABSTRACT
Gastrointestinal endocrine cell tumors are a heterogeneous population of lesions believed to arise from neuroendocrine cells of the gastrointestinal mucosa. The current classification of these tumors is based on tumor size, microscopic features and clinical evidence of metastasis. Although diagnostic categories generally correlate with prognosis, molecular prognostic markers will be clinically useful adjuncts. Cofilin has been implicated in tumor invasion, and its immunolocalisation was studied in gastrointestinal endocrine cell tumors. The immunolocalisation of cofilin was studied by immunohistochemistry in 34 formalin-fixed, paraffin wax-embedded gastrointestinal endocrine cell tumors using a tissue microarray platform. A significant correlation was found between high cofilin immunolabelling and the depth of invasion (p<0.05). Our findings suggest that cofilin might be useful clinically as a molecular prognostic adjunct in the evaluation of gastrointestinal endocrine cell tumors.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Endócrinas / Células Enteroendócrinas / Fatores de Despolimerização de Actina Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Endócrinas / Células Enteroendócrinas / Fatores de Despolimerização de Actina Idioma: En Ano de publicação: 2010 Tipo de documento: Article