A20: central gatekeeper in inflammation and immunity.
J Biol Chem
; 284(13): 8217-21, 2009 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-19008218
ABSTRACT
Inappropriate functioning of the immune system is linked to immune deficiency, autoimmune disease, and cancer. It is therefore not surprising that intracellular immune signaling pathways are tightly controlled. One of the best studied transcription factors in immune signaling is NF-kappaB, which is activated by multiple receptors and regulates the expression of a wide variety of proteins that control innate and adaptive immunity. A20 is an early NF-kappaB-responsive gene that encodes a ubiquitin-editing protein that is involved in the negative feedback regulation of NF-kappaB signaling. Here, we discuss the mechanism of action of A20 and its role in the regulation of inflammation and immunity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
/
Transdução de Sinais
/
Peptídeos e Proteínas de Sinalização Intracelular
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Imunidade Inata
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Inflamação
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article