Modulation of M-current by intracellular Ca2+.
Neuron
; 6(4): 533-45, 1991 Apr.
Article
em En
| MEDLINE
| ID: mdl-1901717
ABSTRACT
IM is a voltage- and time-dependent K+ current that is suppressed by muscarinic receptor activation. IM augmentation following agonist washout was blocked by heavily buffering [Ca2+]i using BAPTA. Although IM is not primarily Ca2+ dependent, small increases in [Ca2+]i by photolysis of the "caged" Ca2+ chelator nitr-5 or by evoking action potentials augmented, while larger increases inhibited, IM. Raising [Ca2+]i for prolonged periods, by nitr-5 photolysis, reduced its sensitivity to agonist, leaving a poorly reversible response. These results suggest that IM can be regulated by physiologically relevant changes in [Ca2+]i, placing IM in a unique position to modulate cell excitability.
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Base de dados:
MEDLINE
Assunto principal:
Potássio
/
Sistema Nervoso Simpático
/
Cálcio
/
Membranas Intracelulares
/
Neurônios
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article