p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling.
Biochimie
; 91(3): 320-8, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19022332
ABSTRACT
p120-RasGAP (Ras GTPase activating protein) plays a key role in the regulation of Ras-GTP bound by promoting GTP hydrolysis via its C-terminal catalytic domain. The p120-RasGAP N-terminal part contains two SH2, SH3, PH (pleckstrin homology) and CaLB/C2 (calcium-dependent phospholipid-binding domain) domains. These protein domains allow various functions, such as anti-/pro-apoptosis, proliferation and also cell migration depending of their distinct partners. The p120-RasGAP domain participates in protein-protein interactions with Akt, Aurora or RhoGAP to regulate functions described bellow. Here, we summarize, in angiogenesis and cancer, the various functional roles played by p120-RasGAP domains and their effector partners in downstream signaling.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas ras
/
Proteínas Ativadoras de ras GTPase
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Proteína p120 Ativadora de GTPase
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article