The structure of the efflux pump AcrB in complex with bile acid.
Mol Membr Biol
; 25(8): 677-82, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-19023693
ABSTRACT
Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Escherichia coli
/
Proteínas Associadas à Resistência a Múltiplos Medicamentos
/
Ácido Desoxicólico
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article