Preferential activation of circulating CD8+ and gammadelta T cells in patients with active Behçet's disease and HLA-B51.
Clin Exp Rheumatol
; 26(4 Suppl 50): S59-63, 2008.
Article
em En
| MEDLINE
| ID: mdl-19026117
ABSTRACT
OBJECTIVE:
To evaluate the activation status of circulating CD4+, CD8+, and gammadelta T cells in patients with active and inactive Behçet's disease (BD).METHODS:
We studied 11 subjects with active BD, 28 with inactive BD, and 13 healthy controls. The expression of CD4, CD8, pan-gammadelta, Vdelta1, and Vdelta2 along with the early activation marker CD69 was analyzed by 3-color flow cytometry.RESULTS:
Proportions of activated CD8+ and gammadelta T cells were significantly greater in patients with active BD than in those with inactive BD or healthy control subjects, but the proportion of activated CD4+ T cells did not differ among these 3 groups. In addition, significantly greater proportions of the Vdelta1+ and Vdelta2+ gammadelta T-cell subsets were activated in patients with active BD than in those with inactive BD or healthy controls; in active BD, the balance of activation between these subsets favored the Vdelta1+ T cells. No significant differences in these proportions were found between subjects with inactive BD and healthy controls. These findings were observed exclusively in patients with HLA-B51. A comparison of samples from 5 patients taken during active BD and after resolution of BD-related symptoms showed the proportions of activated CD8+ and gammadelta T cells dropped when the patients' BD became inactive.CONCLUSION:
CD8+ and gammadelta T cells, rather than CD4+ T cells, were activated in vivo in patients with active BD and HLA-B51, but not in those with inactive BD, suggesting that these potentially cytotoxic T cells play a critical role in BD flares.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA-B
/
Síndrome de Behçet
/
Subpopulações de Linfócitos T
/
Linfócitos T CD8-Positivos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article