Peptide cyclization via ring-closing metathesis: the N-alkenoxy peptide approach.
Org Biomol Chem
; 6(24): 4575-81, 2008 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-19039366
ABSTRACT
The preparation of cyclic hexapeptides from N-hydroxy tripeptides building blocks is described. Introduction of an unsaturated chain on the hydroxamate oxygen followed by fragment coupling leads to N,N'-dialkenoxy hexapeptides that are efficiently cyclized through a ring-closing metathesis reaction. The length of the alkene chains allows the modulation of the ring size the synthesis of 17- and 18-membered cycles is reported.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Alcenos
/
Hidróxidos
/
Nitrogênio
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article