Phosphorylation of nucleosides and nucleotides with inorganic monoimido-cyclo-triphosphate.
Chem Pharm Bull (Tokyo)
; 56(12): 1698-703, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-19043242
ABSTRACT
The phosphorylation of nucleosides (adenosine, guanosine, cytidine, and uridine) and nucleotides (adenosine 5'-monophosphate, guanosine 5'-monophosphate, cytidine 5'-monophosphate and uridine 5'-monophosphate) has been achieved using inorganic monoimido-cyclo-triphosphate (MCTP, Na(3)P(3)O(8)NH) in aqueous solution. In this reaction, the 2'-OH or 3'-OH group of the beta-D-ribofuranose unit was phosphorylated and the total yield was more than 30% and 14%, respectively. The main products were 2'-diphosphoramidophosphononucleoside and 2'-diphosphoramidophosphononucleoside 5'-monophosphate.
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Base de dados:
MEDLINE
Assunto principal:
Polifosfatos
/
Imidas
/
Nucleosídeos
/
Nucleotídeos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article