A synthetically simple, click-generated cyclam-based zinc(II) sensor.
Inorg Chem
; 48(1): 319-24, 2009 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-19053845
ABSTRACT
A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(II) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(II) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(II) flux that exists during apoptotic cell death.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Corantes Fluorescentes
/
Compostos Heterocíclicos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article