Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry.
Atherosclerosis
; 204(2): e86-92, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19054514
ABSTRACT
OBJECTIVES:
To examine differences in risk factor (RF) management between peripheral artery disease (PAD) and coronary artery (CAD) or cerebrovascular disease (CVD), as well as the impact of RF control on major 1-year cardiovascular (CV) event rates.METHODS:
The REACH Registry recruited >68000 outpatients aged >or=45 years with established atherothrombotic disease or >or=3 RFs for atherothrombosis. The predictors of RF control that were evaluated included (1) patient demographics, (2) mode of PAD diagnosis, and (3) concomitant CAD and/or CVD.RESULTS:
RF control was less frequent in patients with PAD (n=8322), compared with those with CAD or CVD (but no PAD, n=47492) [blood pressure; glycemia; total cholesterol; smoking cessation (each P<0.001)]. Factors independently associated with optimal RF control in patients with PAD were male gender (OR=1.9); residence in North America (OR=3.5), Japan (OR=2.5) or Latin America (OR=1.5); previous coronary revascularization (OR=1.3); and statin use (OR=1.4); whereas prior leg amputation was a negative predictor (OR=0.7) (P<0.001). Optimal RF control was associated with fewer 1-year CV ischemic symptoms or events.CONCLUSIONS:
Patients with PAD do not achieve RF control as frequently as individuals with CAD or CVD. Improved RF control is associated with a positive impact on 1-year CV event rates.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Trombose
/
Doenças Cardiovasculares
/
Doenças Vasculares Periféricas
/
Aterosclerose
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article