Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties.
Bioorg Med Chem Lett
; 19(1): 31-5, 2009 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-19062274
ABSTRACT
A series of alpha-amidosulfones were found to be potent and selective agonists of CB(2). The discovery, synthesis, and structure-activity relationships of this series of agonists are reported. In addition, the pharmacokinetic properties of the most promising compounds are profiled.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfonas
/
Receptor CB2 de Canabinoide
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article