Synthesis and rheological properties of hydrogels based on amphiphilic alginate-amide derivatives.
Carbohydr Res
; 344(2): 223-8, 2009 Jan 26.
Article
em En
| MEDLINE
| ID: mdl-19084823
ABSTRACT
New amphiphilic derivatives of sodium alginate were prepared by covalent attachment of dodecylamine onto the polysaccharide via amide linkages at different substitution ratios, using 2-chloro-1-methylpyridinium iodide (CMPI) as coupling reagent. The aim was to limit the progressive loss of associative behaviour which occurs in the case of previously described dodecyl ester alginate derivatives due to hydrolysis of ester bonds. A series of hydrogels was obtained which differed by the amount of attached dodecyl tails. The stability and viscoelastic properties were evaluated and compared to those of hydrogels obtained with alginate esters. The observed differences were discussed in relation to the synthesis procedures. The advantages of amide links are underlined, especially with regard to long-term stability of hydrogels.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hidrogéis
/
Alginatos
/
Amidas
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article