Anti human immunodeficiency virus-1 (HIV-1) agents 1. Discovery of benzyl phenyl ethers as new HIV-1 inhibitors in vitro.
Chem Pharm Bull (Tokyo)
; 57(1): 84-6, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19122322
ABSTRACT
Ten single benzyl phenyl ethers were synthesized and evaluated as human immunodeficiency virus-1 (HIV-1) inhibitors in vitro for the first time. Among these compounds, especially 4-nitrobenzyl phenyl ether (3h) exhibited the highest anti-HIV-1 activity with EC50 (concentration of drug that reduces syncytia formation by 50%) value of 5.96 microg/ml and therapeutic index value of 18.32. The preliminary structure-activity relationships of these benzyl phenyl ethers were also described.
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Base de dados:
MEDLINE
Assunto principal:
Éteres Fenílicos
/
HIV-1
/
Fármacos Anti-HIV
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article