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Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor.
Witherington, Jason; Abberley, Lee; Bellenie, Benjamin R; Boatman, Rio; Collis, Katharine; Dean, David K; Gaiba, Alessandra; King, N Paul; Shuker, Nicola; Steadman, Jon G A; Takle, Andrew K; Sanger, Gareth; Butler, Sharon; McKay, Fiona; Muir, Alison; Winborn, Kim; Ward, Robert W; Heightman, Tom D.
Afiliação
  • Witherington J; Department of Medicinal Chemistry & DMPK, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Jason_Witherington@GSK.com
Bioorg Med Chem Lett ; 19(3): 684-7, 2009 Feb 01.
Article em En | MEDLINE | ID: mdl-19128969
As part of an on-going lead optimisation effort, a cross screening exercise identified an aryl sulphonyl amide hit that was optimised to afford a highly potent series of ghrelin receptor agonists.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonas / Química Farmacêutica / Grelina / Receptores de Grelina Idioma: En Ano de publicação: 2009 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonas / Química Farmacêutica / Grelina / Receptores de Grelina Idioma: En Ano de publicação: 2009 Tipo de documento: Article