A small molecule that binds Hedgehog and blocks its signaling in human cells.
Nat Chem Biol
; 5(3): 154-6, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19151731
ABSTRACT
Small-molecule inhibition of extracellular proteins that activate membrane receptors has proven to be extremely challenging. Diversity-oriented synthesis and small-molecule microarrays enabled the discovery of robotnikinin, a small molecule that binds the extracellular Sonic hedgehog (Shh) protein and blocks Shh signaling in cell lines, human primary keratinocytes and a synthetic model of human skin. Shh pathway activity is rescued by small-molecule agonists of Smoothened, which functions immediately downstream of the Shh receptor Patched.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Proteínas Hedgehog
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Lactamas
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Lactonas
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article