The functions of Munc18-1 in regulated exocytosis.
Ann N Y Acad Sci
; 1152: 76-86, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19161378
ABSTRACT
The activation of regulated exocytosis occurs by a rise in cytosolic Ca(2+) concentration. Synaptotagmins act as the Ca(2+) sensors, whereas the machinery that allows fusion of secretory vesicles with the plasma membrane consists of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, including syntaxin 1, SNAP-25, and VAMP. Within the pathway leading to exocytosis, there is an essential requirement for a member of the conserved Sec1/Munc18 (SM) protein family, which in neurotransmitter and neurohormone release in mammalian cells is Munc18-1. The exact role of Munc18-1 and the steps within exocytosis in which it acts have been intensively investigated. Current evidence suggests that Munc18-1 acts via distinct modes of interactions with syntaxin 1 and the other SNARE proteins and influences all of the steps leading to exocytosis, including vesicle recruitment, tethering, docking, priming, and membrane fusion.
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1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Munc18
/
Exocitose
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article