Transcriptional activity of interferon gamma and two subunits of its receptor as molecular markers of myocarditis.
Acta Pol Pharm
; 65(6): 685-9, 2008.
Article
em En
| MEDLINE
| ID: mdl-19172849
ABSTRACT
Inflammatory cytokines have an important role in the pathogenesis of myocarditis, but still little is known about the importance of interferon gamma (IFNg) in this disease. The aim of the study was to evaluate the prognostic value of the initial transcriptional activity of IFNg and two subunits of its receptor as measured with the use of QRT-PCR and SYBRGreen chemistry in the group of 63 patients with clinically confirmed myocarditis who were treated with statin or immunosupressive therapy. The initial values of IFNg and the ratio of IFNgRb/IFNgRa were statistically different in the analyzed group of patients. The prognostic value of IFNg and IFNgRb/IFNgRa was determined by logistic regression analysis.
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Base de dados:
MEDLINE
Assunto principal:
Interferon gama
/
Receptores de Interferon
/
Miocardite
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article