(1,2,3-Triazol-4-yl)benzenamines: synthesis and activity against VEGF receptors 1 and 2.
Bioorg Med Chem Lett
; 19(5): 1344-8, 2009 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-19188066
Derivatives of (1,2,3-triazol-4-yl)benzenamines are described as potent and ATP-competitive inhibitors of vascular endothelial growth factor receptors I and II (VEGFR-1/2). A number of compounds exhibited VEGFR-2 and VEGFR-1 inhibitory activity comparable to that of Vatalanib in both HTRF enzymatic and cellular assays.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triazóis
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Derivados de Benzeno
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Receptor 1 de Fatores de Crescimento do Endotélio Vascular
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Receptor 2 de Fatores de Crescimento do Endotélio Vascular
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article