Molecular modeling studies of ABC transporters involved in multidrug resistance.
Mini Rev Med Chem
; 9(2): 186-93, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19200023
ABSTRACT
Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Resistência a Múltiplos Medicamentos
/
Transportadores de Cassetes de Ligação de ATP
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article