Calcium regulating hormones and serum calcium and magnesium concentrations in septic and critically ill foals and their association with survival.
J Vet Intern Med
; 23(2): 335-43, 2009.
Article
em En
| MEDLINE
| ID: mdl-19210311
ABSTRACT
BACKGROUND:
Disorders of calcium regulation are frequently found in humans with critical illness, yet limited information exists in foals with similar conditions including septicemia. The purpose of this study was to determine whether disorders of calcium exist in septic foals, and to determine any association with survival.HYPOTHESIS:
Blood concentrations of ionized calcium (Ca(2+)) and magnesium (Mg(2+)) will be lower in septic foals with concomitant increases in parathyroid hormone (PTH), calcitonin (CT), and parathyroid-related peptide (PTHrP) compared with healthy foals. The magnitude of these differences will be negatively associated with survival. ANIMALS Eighty-two septic, 40 sick nonseptic, and 24 healthy foals ofRESULTS:
Septic foals had decreased Ca(2+) (5.6 versus 6.1 mg/dL, P < .01) and increased serum PTH (16.2 versus 3.2 pmol/L, P < .05), and phosphorus concentrations (7.1 versus 6.3 mg/dL, P < .01). No differences in serum Mg(2+), PTHrP, and CT concentrations were found. Nonsurviving septic foals (n = 42/82) had higher PTH concentrations (41.1 versus 10.7 pmol/L, P < .01) than survivors (n = 40/82). CONCLUSIONS AND CLINICAL IMPORTANCE Septic foals were more likely to have disorders of calcium regulation compared with healthy foals, where hyperparathyroidemia was associated with nonsurvival.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
Sepse
/
Hormônios Peptídicos
/
Doenças dos Cavalos
/
Magnésio
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article