Late onset Pneumocystis pneumonia in renal transplantation after long-term immunosuppression with belatacept.
Transpl Infect Dis
; 11(2): 171-4, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19210692
ABSTRACT
Interference with T-cell function increases the risk of infections, especially during the early post-transplant period. Belatacept, a costimulation blocker, is currently being tested in phase III clinical trials. Here we report a renal transplant recipient who received belatacept and developed severe Pneumocystis jirovecii pneumonia (PCP) with fatal superinfections 4 years post transplant. Cytomegalovirus infection preceded PCP, which typically occurs in overimmunosuppressed patients, but has not yet been reported under T-cell costimulation blockade in transplant patients. This case illustrates the possibility of excessive immunosuppression even with a lymphocyte-specific regimen.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia por Pneumocystis
/
Complicações Pós-Operatórias
/
Superinfecção
/
Transplante de Rim
/
Imunoconjugados
/
Pneumocystis carinii
/
Imunossupressores
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article