Enantioselective three-component Kabachnik-Fields reaction catalyzed by chiral scandium(III)-N,N'-dioxide complexes.
Org Lett
; 11(6): 1401-4, 2009 Mar 19.
Article
em En
| MEDLINE
| ID: mdl-19226133
ABSTRACT
The N,N'-dioxide-Sc(III) complex has been applied in the three-component Kabachnik-Fields reaction of aldehydes, 2-aminophenol, and diphenyl phosphite, giving the corresponding alpha-amino phosphonates in good yields with high enantioselectivities (up to 87% ee). The direct Kabachnik-Fields reaction proceeded with extremely high reactivity under mild reaction conditions and could be used for large-scale synthesis of the alpha-amino phosphonates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Escândio
/
Aldeídos
/
Organofosfonatos
/
Aminofenóis
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article