Autoregulatory feedback loops terminating the NF-kappaB response.
Trends Biochem Sci
; 34(3): 128-35, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19233657
After nuclear factor (NF)-kappaB activation, a complex network of negative feedback loops ensures that the termination of the NF-kappaB response occurs in a highly organized manner. Recent results show that signals initiated during the induction phase already program a default termination procedure that enables temporally and spatially regulated NF-kappaB deactivation. All negative feedback mechanisms occur with a characteristic time delay, thereby permitting full NF-kappaB function during the interim period. Some proteins that direct termination are produced directly in response to NF-kappaB activation, whereas others are activated via inducible binding or by protein stabilization. Another time-delaying strategy of NF-kappaB feedback inhibitory proteins relies on their ability to function as timers and molecular clockworks with the intrinsic property to terminate their own activity within a preset period.
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Base de dados:
MEDLINE
Assunto principal:
NF-kappa B
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Homeostase
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article