The unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistry.
Ann N Y Acad Sci
; 1155: 316-23, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19250223
ABSTRACT
6-Hydroxydopamine (6-OHDA) is a neurotoxic compound commonly used to induce dopamine (DA) depletion in the nigrostriatal system, mimicking Parkinson's disease (PD) in animals. The aim of the present study was to evaluate the 7-day effect of unilateral nigral lesion on rat brain monoamine neurochemistry. Five brain regions were examined the brain stem, cerebellum, hippocampus, striatum, and cortex. 6-OHDA-unilateral lesion dramatically modified DA, serotonin (5-HT) and their metabolites contents in both sides of the different brain nuclei. Furthermore, unilateral 6-OHDA lesion reduced DA and 5-HT contents and produced a robust inversion of their turnover in the nonlesioned side compared to sham-operated rats. These data suggest that 6-OHDA unilateral nigral lesion produces bilateral monoamine level modifications, and this piece of evidence should be taken into account when one interprets data from animal models of unilateral PD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Substância Negra
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Monoaminas Biogênicas
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article